To Drive From Downtown Orlando To 105 N Florida Ave In Howey In The Hills, Start By Heading West On West South Street Toward South Orange Avenue. Merge Onto I-4 West, Following Signs For Tampa. After A Short Drive, Take Exit 72 To Merge Onto Fl-429 North Toward Apopka. Continue On Fl-429 North, And Then Merge Onto Us-441 South. Take The Exit For Fl-19 South, Which Will Lead You Toward Howey In The Hills. Finally, Continue On Fl-19 South And Make A Left Turn Onto North Florida Avenue, Where Your Destination Will Be On The Right.